The two most unfortunate people in the world are the two people involved in a knife fight. One of them is going to die, and the other will probably die as well if he doesn't get medical attention quickly enough. It's not like you see in the movies, carefully choreographed and all.
Watch a prison shanking video. THAT is how it actually happens in real life. Fast and brutal.
This is why I carry a gun.
That said, if I had to use a SYKCO knife to defend myself, my first choice would be the Yard Guard. Second choice would be the Yard Hook. Third choice would be the SOD.
But choice of knife is a very personal matter... different philosophies, training regimens and approaches result in different choices in blades. Personally... my favorite fighters, for real-world carrying and use, are made by Al Polkowski.