As I understand it from a discussion when they were first released, right-handed 'vores have the handle's pry bevel down when held in your right hand by the blade, with the spine against your palm (so that you don't slice your hand open). The left-handled models would be the same when held in the left hand.

I don't know whether the sheaths will be available in other colors, but I requested orange sheaths (if available) in my order comments -- I figure it never hurts to ask, although I suspect they won't be.