The home in smoke idea goes right along with the eggs in one basket concept. What ever your most likely threat is would be something to build for/against to increase your odds of surviving said disaster.
Things to consider based on your threat area.
Floods: consider building higher up if you can and definitely out of a floodplain. If not, look into ways to increase drainage out of your home and decrease drainage in. French drains work wonders.
Earthquakes: consider a building method that has flexibility with the land like strawbale walls. Stick built or stone/brick/mortar are extremely rigid.
Fires: consider a house that is very hard to burn like stone/brick/block/strawbale and keep your property cleared of as many fire hazards as possible, and remember to keep a good water supply on hand to fight/protect the place.
Hurricanes/Tornadoes: build partially or completely into/underground or at least store your most important valuables in a storm cellar, hopefully high enough up to not get flooded.
Drought: Stockpile as much water as you can possibly can, though it may not be cheap. Water is the most important thing to have, period.

There is also always the option to look at relocation to safer environments as well, and it may be cheaper in the long run. Stepping out of the circle of comfort is hard for many but not impossible.