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Re: Run for the porch [Re: greaser] #743175 02/12/13 05:41 AM
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ok my relief here so I am out. take care


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Re: Run for the porch [Re: greaser] #743176 02/12/13 05:43 AM
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later


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Re: Run for the porch [Re: tedsterosa] #743177 02/12/13 05:56 AM
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this next module is really dense


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Re: Run for the porch [Re: tedsterosa] #743178 02/12/13 05:57 AM
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DHFR enzymes


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Re: Run for the porch [Re: tedsterosa] #743179 02/12/13 05:58 AM
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the amino acid sequences of DHFR are similar across species


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Re: Run for the porch [Re: tedsterosa] #743180 02/12/13 05:58 AM
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but it's the amino acid sequence of the gene.


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Re: Run for the porch [Re: tedsterosa] #743181 02/12/13 05:58 AM
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small differences in shapes of mammal DHFR and plasmodium DHFR


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Re: Run for the porch [Re: tedsterosa] #743182 02/12/13 05:59 AM
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pyrimethamine binds more tightly to parasite enzyme than human enzyme


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Re: Run for the porch [Re: tedsterosa] #743183 02/12/13 06:00 AM
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Selectivity of drugs, accumulation difference between parasite and host.


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Re: Run for the porch [Re: tedsterosa] #743184 02/12/13 06:01 AM
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chemotherapies are selective poisons


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Re: Run for the porch [Re: tedsterosa] #743185 02/12/13 06:01 AM
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hustly bustly


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Re: Run for the porch [Re: tedsterosa] #743186 02/12/13 06:02 AM
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drug resistance malaria


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