I would hate to leave my 12 gauge at home....it would be heavy, but with the right round.....you can do about anything. Maybe a combo shotgun with a 22..... You could hog a bunch of 22 ammo and not break your back. I am most comfortable with my glock 22, but if ammo was restricted, I would opt for a 17 or 19. The knife....only one is tough. Again it depends where you are. I might opt for my Bolo machete in a heavly wooded situation. We need some scenario's.