Dan,
Did you look into the S&W 460. It takes nor only the 460 but the 454 and 45 long colt too. I will be getting one in there survival kit soon.
I did look into the 460 but it is like a 454 on steroids, not much fun to shoot. The 454's are ok and 45's feel like a 22 plinker.
My favorite caliber has always been the 44 mag. I have been shooting one since I was 14 year sold, but it has been replaced by the 500 S&W because of inherent accuracy with all loads and the little felt recoil/kick.
Dan