I would suspect that center fire ammo would be more reliable than a rim fire cartridge, but I've never had any issues with that. Also you can get parts for the new gun and the Grendel has been abandoned long ago.
Very good points. I guess if I am worried about the reliability I might purchase solely CCI etc. but then the price starts increasing also. The bullet design is likely quite a bit better. For a survival type pistol your final point may be the most important. Looking on gunbroker there do seem to be quite a few parts available but that does not mean I would be able to purchase the part I need in a time of need.
Getting my Zombie kit ready and watching out for those Corpse Men!!!