I am not sure what your anticipated use for the weapon will be. If it is deer hunting, go with the Ruger 30-06. You have personal defense covered with the .380, but a full 9mm Luger round does pack more power and range. Same size hole. If you don't already own a .22, get the Ruger 10/22. The lowly .22LR is the ultimate survival gun. And while it won't pierce body armor or kill at 300 yds, it is plenty deadly for close range if you place your shots. Ammo is cheap and readily available most of the time. And as 22s go, the 10/22 is easily the most popular one on this forum.