I have a Single Six. Love it! I can run shorts in it if I don't want to attract too much attention. Just a nice gun. All my Ruger revolvers are--3 Blackhawks of varying size.
Also have a 22/45 with a threaded barrel. Someday, I may supress it but not right now. If you get one, buy the Tandemkross bushing and LCI replacement parts. The gun will perform much better and it'll only run ya about 20bucks. I put cocobolo burl grips on mine from a Puerto Rican maker on ebsy. Beautiful. Mine came with fixed rear sights that I replaced with an adjustable one. I can now throw whatever I wsnt on it--fiber optics, ghost ring, etc. I also have a rail for it should I decide to throw a red dot on it. Point is there are tons of 22/45 models to meet your needs and they are customizable. Also great for if you intend to get a 1911 since the 22/45 config is based on the 1911.
Bug out? get a 22!45 lite and buy a supressor. Fiber optis, theaded barrel, and fluted to keep weight down.