10/22 is a great survival rifle. Personally, I wouldn't want to be "only armed" with a 22LR for SHTF defense, but it certainly beats throwing rocks.

I'm a firm believer in 22 rifles or handguns for general survival purposes. I've never heard a valid argument to the contrary.

I think it best to carry a centerfire rifle and keep a 22LR handgun or take-down type rifle in your ruck. The handgun could be carried on your hip for fast access (when dat tasty wabbit woefully wonders acwoss ywo paff). Otherwise, it (or a folding stock 10/22 or Marlin 70 Papoose) can ride in or on your BOB.