If the firearm in question is a strong modern action it can be loaded up to very impressive levels
A Ruger #1 can be hot loaded to ALMOST approach 458 winning
I have a 450 marlin which is essentially a modern 45/70 and there isn't anything on North America that I wouldn't hunt with it

Now the 375 H&H is in a completely different class than the 45/70 both in terms of versatility and reach

The only animal that I have personally seen shot with a 375 was a grizzly that my brother harvested a couple of years ago

The 375 hit with AUTHORITY