Yes in parts of Africa .375H&H is the minimum for dangerous game, some argue that it is light on for Cape Buffalo but I am willing to bet it will serve me just fine (as it has many many others). I have taken more than my share of Asiatic Buffalo with mine (a looooong time ago now) and I was knocking the snot out of them with 300gn Sierras. They are arguably as hard as a Cape Buff just not as romanticised Newer projectiles such as the Woodleigh Hydros lift them up further in performance.

I can also use my H&H day in and out without ill effect, many 45/70s will pummel you worse !!! That said, I would love a marlin "Guide Gun" in 45/70...!!!!!